OperaV1, Main, Exploration, bibRecord, 000911

Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice

Identifieur interne : 000911 ( Main/Exploration ); précédent : 000910; suivant : 000912

Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice

Auteurs : M. Uchiyama [Japon] ; X. Jin [Japon, République populaire de Chine] ; Q. Zhang [Japon] ; A. Amano [Japon] ; T. Watanabe [Japon] ; M. Niimi [Japon]

Source :

Transplantation proceedings [ 0041-1345 ] ; 2012.

RBID : Pascal:12-0238595

Descripteurs français

Pascal (Inist)
- Homotransplantation, Musique, Exposition, Coeur, Survie, Pronostic, Lymphocyte T, Animal, Souris, Médecine, Transplantation, Greffe, Traitement, Antigène CD4, Cellule régulatrice.
Wicri :
- topic : Musique, Médecine.

English descriptors

KwdEn :
- Animal, Exposure, Graft, Heart, Homotransplantation, Medicine, Mouse, Music, Prognosis, Regulatory cell, Survival, T-Lymphocyte, Transplantation, Treatment.

Abstract

In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naive and eardrum-ruptured CBA/N (CBA, H2^K) underwent transplantation of a C57BL/6 (B6, H2^b) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4⁺ cells, and CD4⁺CD25⁺ cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-y were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4⁺CD25⁺Foxp3⁺ cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4⁺CD25⁺Foxp3⁺ regulatory cells.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000092
to stream PascalFrancis, to step Curation: 000434
to stream PascalFrancis, to step Checkpoint: 000064
to stream Main, to step Merge: 000909
to stream Main, to step Curation: 000911

Le document en format XML

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 Cells in Mice</title>
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<author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M." last="Niimi">M. Niimi</name>
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<series><title level="j" type="main">Transplantation proceedings</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Exposure</term>
<term>Graft</term>
<term>Heart</term>
<term>Homotransplantation</term>
<term>Medicine</term>
<term>Mouse</term>
<term>Music</term>
<term>Prognosis</term>
<term>Regulatory cell</term>
<term>Survival</term>
<term>T-Lymphocyte</term>
<term>Transplantation</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homotransplantation</term>
<term>Musique</term>
<term>Exposition</term>
<term>Coeur</term>
<term>Survie</term>
<term>Pronostic</term>
<term>Lymphocyte T</term>
<term>Animal</term>
<term>Souris</term>
<term>Médecine</term>
<term>Transplantation</term>
<term>Greffe</term>
<term>Traitement</term>
<term>Antigène CD4</term>
<term>Cellule régulatrice</term>
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<front><div type="abstract" xml:lang="en">In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naive and eardrum-ruptured CBA/N (CBA, H2<sup>K</sup>
) underwent transplantation of a C57BL/6 (B6, H2<sup>b</sup>
) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4<sup>+</sup>
 cells, and CD4<sup>+</sup>
CD25<sup>+</sup>
 cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-y were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4<sup>+</sup>
CD25<sup>+</sup>
Foxp3<sup>+</sup>
 cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4<sup>+</sup>
CD25<sup>+</sup>
Foxp3<sup>+</sup>
 regulatory cells.</div>
</front>
</TEI>
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<name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A." last="Amano">A. Amano</name>
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<name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M." last="Niimi">M. Niimi</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X." last="Jin">X. Jin</name>
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</record>

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Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice

Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri